| Abstract: | We demonstrate that, in human bladder cancer, ampli.-
cation of the E2F3 gene, located at 6p22, is associated
with overexpression of its encoded mRNA transcripts and
high levels of expression of E2F3 protein. Immunohistochemical
analyses of E2F3 protein levels have established
that around one-third (33/101) of primary transitional cell
carcinomas of the bladder overexpress nuclear E2F3
protein, with the proportion of tumours containing overexpressed
nuclear E2F3 increasing with tumour stage and
grade. When considered together with the established role
of E2F3 in cell cycle progression, these results suggest
that the E2F3 gene represents a candidate bladder cancer
oncogene that is activated by DNA ampli.cation and
overexpression. |
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